"What we would all like [...] is an understanding of the fundamental processes that govern the Universe, an understanding that is not just useful for calculation but an understanding that is true in some deeper sense. Typically, a scientist sees the latter point as either obvious and important, or else completely irrelevant. I would like to argue that we don’t have a choice; there is some very clear sense in which truth is not what is returned by any finite scientific investigation; all that is returned is plausibilities (some of which become very very high), and those plausibilities relate not directly to the truth of the hypotheses in question, but rather to their use or value in describing the data.
The fundamental reason scientific investigations can’t obtain literal truth is that no scientific investigator ever has an exhaustive (and mutually exclusive) set of hypotheses. Plausibility calculations are calculations of measure in some space, which for our purposes we can take to be the space formed by the union of every possible set of scientific hypotheses, with their parameters and adjustments set to every possible set of values." -- David Hogg, Is cosmology just a plausibility argument?.